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. 1980:74:72-7.
doi: 10.1007/978-3-642-81488-4_10.

N-(Phosphonacetyl)-L-aspartate (PALA): current status

M Rozencweig, R Abele, M Piccart, D D Von Hoff, F M Muggia

N-(Phosphonacetyl)-L-aspartate (PALA): current status

M Rozencweig et al. Recent Results Cancer Res. 1980.

Abstract

N-(Phosphonoacetyl)-L-aspartate (PALA) is a synthetic antimetabolite exhibiting striking oncolytic properties against a wide variety of experimental solid tumors. The clinical dose-limiting factor is mucocutaneous toxicity which is reversible and dose-related. Delineation of the single-agent activity of PALA in human cancer must still await results of recently activated trials.

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