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. 1980;51(3):237-9.
doi: 10.1007/BF00687391.

Polysaccharide accumulation in the central nervous system of D-penicillamine-treated rats

A P Jayaraj

Polysaccharide accumulation in the central nervous system of D-penicillamine-treated rats

A P Jayaraj. Acta Neuropathol. 1980.

Abstract

A complex polysaccharide accumulation was observed in the central nervous system (CNS) of rats treated with D-penicillamine similar to Lafora-like bodies. They have histochemical similarities comparable to bodies described in previous studies of Lafora disease. The clinical usefulness of D-penicillamine has been limited by many side effects including renal damage. It is suggested that, in addition to D-penicillamine nephropathy, there are toxic effects of this drug on the CNS.

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