Long-term morphology of the alumina cream experimental epileptogenic focus

Abstract

A morpholigical study of an experimental epileptogenic focus in the cat, eighteen months after intracerebral injection of alumina cream, is presented. The most significant histological findings were cortical atrophy and reactive gloisis enclosing the implantedd particles. Subpial sclerosis and evidence of ischaemic neuronal lesions were also found. These findings confirm a close morphological relation between the alumina cream experimental focus obtained after a certain period of evolution and the human epileptogenic focus.