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Comparative Study
. 1980;21(3):415-27.
doi: 10.1186/BF03546874.

Listeriosis in sheep. Experimental listeric infection in sheep treated with various immunosuppressiva

H Grønstøl
Comparative Study

Listeriosis in sheep. Experimental listeric infection in sheep treated with various immunosuppressiva

H Grønstøl. Acta Vet Scand. 1980.

Abstract
in English, Norwegian

Four groups of lambs, about 6 months old, were given 4 different immunosuppressiva (prednisolone, cyclophosphamide, niridazole and gestagene hormones), 1 substance to each group. After this treatment the 4 groups together with a 5th group of the same size, were infected with Listeria monocytogenes (Lm).

None of the animals developed clinical listeric encephalitis. The level of antibodies differed between the groups. The group not given any immun osuppressivum reached the highest antibody titres, the group given gestagene hormones had the lowest titres and the other groups ranged somewhere inbetween. All the groups except the group treated with niridazole had a strong delayed hypersensitivity reaction against Lm. The effects of the treatment upon some blood components are also described.

Further studies are necessary to establish the effect of various immunosuppressiva, especially gestagene hormones.

Fire grupper av 6 månader garnie lam blei behandla med 4 ulike immunosuppressiva (prednisolon, cyclophosphamate, niridazol, geslagene hormon). Etter behandling blei dei 4 gruppene saman med ei tilsvarande femte ubehandla gruppe infiserte med Listeria monocytogenes (Lm).

Ingen av dyra fekk typisk listeria-encefalitt. Gruppene utvikla ulike nivå av antistoff mot Lm. Mest antistoff blei funne i den gruppa som ikkje hadde fått immunosuppressiva, og minst i den gruppa som hadde fått geslagene hormon. Nivået i dei andre gruppene låg ein stad meilom desse. Alle gruppene utanom den gruppa som hadde fått niridazol viste ein sterk seinka hypersensitivitetsreaksjon mot Lm. Eit oversyn over verknaden på ulike blodkomponentar er og gjeve.

Forsøket synte at vidare studier trengst for å finna meir ut om korleis ulike immunosuppressiva, og sserleg då gestagene hormon, verkar på immuniteten mot mikroorganismar.

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References

    1. Anon.: Progesterone in large amounts has immunosuppressive effect. J. Amer. med. Ass. 1976, 236, 905–906. - PubMed
    1. Bach, J. F.: The mode of action of immunosuppressive agents. North-Holland Research Monographs: Frontiers of Biology, vol. 41. North-Holland Publishing Company, Amsterdam-Oxford 1975, 379 pp. - PubMed
    1. Claman H N. Corticosteroids and lymphoid cells. New Engl. J. Med. 1972;287:388–397. doi: 10.1056/NEJM197208242870806. - DOI - PubMed
    1. Dukor P, Dietrich F M. Chemical suppression of immune response in thymectomized mice. Int. Arch. Allergy. 1967;32:131–148. doi: 10.1159/000229923. - DOI - PubMed
    1. Dukor P, Dietrich F M. Characteristic features of immunosuppression of steroids and cytotoxic drugs. Int. Arch. Allergy. 1968;34:32–48. doi: 10.1159/000230092. - DOI - PubMed

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