Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1980 Oct;18(4):562-5.
doi: 10.1128/AAC.18.4.562.

Comparison of ceforanide, cefazolin, methicillin, and nafcillin in Staphylococcus aureus endocarditis therapy in rabbits

J Carrizosa, W D Kobasa, D Kaye
Comparative Study

Comparison of ceforanide, cefazolin, methicillin, and nafcillin in Staphylococcus aureus endocarditis therapy in rabbits

J Carrizosa et al. Antimicrob Agents Chemother. 1980 Oct.

Abstract

Ceforanide (30 mg/kg) administered every 12 h, cefazolin (20 mg/kg) administered every 8 h and methicillin or nafcillin (40 mg/kg) administered every 6 h were equally effective in reducing the number of Staphylococcus aureus in vegetations in rabbits with endocarditis. These treatments were more effective than methicillin or nafcillin administered every 12 h. Ceforanide produced higher peak concentrations and greater bactericidal activity in serum than the other drugs and had the longest half-life (5.8 h, compared with 0.4 to 0.8 h for the other agents.

PubMed Disclaimer

References

    1. J Clin Invest. 1973 Mar;52(3):592-8 - PubMed
    1. J Infect Dis. 1973 Oct;128:Suppl:S354-7 - PubMed
    1. J Lab Clin Med. 1976 Jul;88(1):132-41 - PubMed
    1. J Lab Clin Med. 1977 Jun;89(6):1262-8 - PubMed
    1. Antimicrob Agents Chemother. 1978 Jan;13(1):74-7 - PubMed

Publication types

MeSH terms