Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980;269(1):13-20.
doi: 10.1007/BF00404453.

The effect of rat serum on the morphology of rat hair follicles in tissue culture

R Frater

The effect of rat serum on the morphology of rat hair follicles in tissue culture

R Frater. Arch Dermatol Res. 1980.

Abstract

Rat hair follicles obtained from the skin of 12-day-old animals were cultured in the presence of 20% fetal calf serum and compared with those cultured in the presence of 20% rat serum obtained from animals aged 12-14, 18-20 days; and 1 year. Follicles cultured in the presence of fetal calf or 12-14-day rat serum showed no morphological change after 2 days of culture. Follicles cultured in the presence of 18-20 day serum or adult serum for 2 days showed greatly altered morphology, the dermal papilla degenerated, keratinization of hair cells occurred, and an enlarged outer sheath developed. The cells in this sheath contained many filaments which were periodic acid-Schiff positive. These changes are compared with those occurring during the catagen phase of the hair cycle in vivo.

PubMed Disclaimer

References

    1. Stain Technol. 1974 Sep;49(5):265-72 - PubMed
    1. J Endocrinol. 1958 Apr;16(4):351-9 - PubMed
    1. J Endocrinol. 1964 May;29:193-201 - PubMed
    1. J Clin Endocrinol Metab. 1974 May;38(5):811-9 - PubMed
    1. J Invest Dermatol. 1959 Dec;33:307-16 - PubMed