Comparative Study
[Globin synthesis in erythroid cultures from normal and thalassemic subjects]
[Article in
Italian]
- PMID: 7448020
Item in Clipboard
Comparative Study
[Globin synthesis in erythroid cultures from normal and thalassemic subjects]
[Article in
Italian]
Boll Soc Ital Biol Sper.
.
Abstract
Relative alpha and beta chain synthesis in erythroid bursts derived from human bone marrow and peripheral blood are presented. The biosynthetic ratios obtained are compared with those of the reticulocytes. The data obtained cell culture are similar to the "in vivo" ones, showing and alpha/beta ratio of 1 in normal individuals and higher than 1 in beta thalassemic heterozygous. The use of erythroid cell culture as an experimental model for the study of differentiation at molecular level is therefore possible.
Similar articles
-
Globin synthesis in fractionated Normoblasts of beta-thalassemia heterozygotes.J Clin Invest. 1975 Mar;55(3):567-78. doi: 10.1172/JCI107964. J Clin Invest. 1975. PMID: 1167870 Free PMC article.
-
Unbalanced globin synthesis in bone marrow of beta-thalassemia heterozygotes.Birth Defects Orig Artic Ser. 1987;23(5A):157-61. Birth Defects Orig Artic Ser. 1987. PMID: 3689894
-
Beta-thalassemia and sickle cell disease in culture of early erythroid precursors: hemoglobin synthesis and ultrastructural study.Blood Cells. 1981;7(1):179-200. Blood Cells. 1981. PMID: 7187747
-
Successful correction of the human Cooley's anemia beta-thalassemia major phenotype using a lentiviral vector flanked by the chicken hypersensitive site 4 chromatin insulator.Ann N Y Acad Sci. 2005;1054:238-49. doi: 10.1196/annals.1345.030. Ann N Y Acad Sci. 2005. PMID: 16339671 Review.
-
Variation in beta-alpha synthesis ratios in thalassemia and hemoglobinopathies.Ann N Y Acad Sci. 1974;232(0):44-53. doi: 10.1111/j.1749-6632.1974.tb20571.x. Ann N Y Acad Sci. 1974. PMID: 4607338 Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical