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Comparative Study
. 1980 Oct;10(4):393-7.
doi: 10.1111/j.1365-2125.1980.tb01776.x.

Comparative efficacy of salbutamol by pressurized aerosol and wet nebulizer in acute asthma

R A Tarala, B W Madsen, J W Paterson
Comparative Study

Comparative efficacy of salbutamol by pressurized aerosol and wet nebulizer in acute asthma

R A Tarala et al. Br J Clin Pharmacol. 1980 Oct.

Abstract

1 Cumulative dose-response curves (FEV1) to pressurized aerosol salbutamol were established in 17 patients admitted to hospital with acute severe asthma. After the maximal pressurized aerosol effect had been achieved, a further dose (5 mg) of salbutamol was given by wet nebulizer and any further increment recorded. 2 Baseline FEV1 was 1.16 +/- 0.55 (mean +/- s.d.), an average of 36% of predicted, and the maximal aerosol induced change in FEV1 was 0.435 +/- 0.330 1 (t = 5.72, P < 0.01). There was an additional, small increment in FEV1 after nebulizer of 0.043 +/- 0.085 1 (t = 2.26, P < 0.05). 3 Detailed analysis of the data according to a theoretical dose-response relationship showed that the nebulizer-aerosol increment was unrelated to asthma severity.

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References

    1. Lancet. 1969 Aug 9;2(7615):279-85 - PubMed
    1. Am Rev Respir Dis. 1972 Jul;106(1):38-46 - PubMed
    1. Am Rev Respir Dis. 1974 Feb;109(2):293-5 - PubMed
    1. Br Med J. 1975 Apr 19;2(5963):119-20 - PubMed
    1. Br J Dis Chest. 1978 Jul;72(3):222-4 - PubMed

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