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. 1980 Oct;61(5):497-504.

Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions

P G Robins

Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions

P G Robins. Br J Exp Pathol. 1980 Oct.

Abstract

It is shown by transmission electron-microscopy that the first structural change in rats, following a dose of aspirin, is to the basement membrane of the endothelial cell of the capillary and post-capillary venule. This leads to the breakdown of small blood vessels before any other cytolytic effect. This is a focal effect and it is proposed that the erosion develops as an ischaemic infarct.

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