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. 1978 Jan 7;1(8054):20-2.
doi: 10.1016/s0140-6736(78)90364-1.

Pool-priming: A means of generating T lymphocytes cytotoxin to tumour or virus-infected cells

M L Bach, F H Bach, J M Zarling

Pool-priming: A means of generating T lymphocytes cytotoxin to tumour or virus-infected cells

M L Bach et al. Lancet. .

Abstract

It is proposed that cells cytotoxic for autologous or syngeneic tumour cells can be produced in vitro by sensitisation of lymphocytes to a pool of normal cells from 20 unrelated individuals. Restriction on molecules that can serve as cytotoxic determinants (C.D.), may explain why a random pool of cells from 20 people could present essentially all of the determinants (C.D.) may explain why a random pool of occur because of extensive cross-reactivity of antigens on tumour cells with normal alloantigens present in the stimulating pool.

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