[Effect of phenobarbital, ethanol and their sequential administration on the functional capacity of liver tissue]

Abstract

It was established in chronic experiments on white rats that 40-day supply to the body of a 0.1% phenobarbital solution instead of drinking water activates microsomal enzymes of hepatocytes. Concurrently, the cholesterol content falls, while the enzymatic activity of blood serum and total acetylating capacity of the body increase. 7-day administration of 5% ethanol instead of drinking water and especially 33-day administration of 0.1% phenobarbital followed by 5% ethanol promote the development of fatty infiltration and tissue decompensation of the liver.