[Effect of complamine, nonachlazine, riboxine and clofeline on the fibrinogen content and fibrinolytic activity of the blood]

Abstract

Single intravenous administration of complamin and riboxin (10 mg/kg) and nonachlazin (7 mg/kg) to white rats of both sexes activates fibrinolysis. Single intravenous administration of clofelin in a dose of 30 micrograms/kg does not exert any effect on this proteolytic process. Chronic experiments on animals given clofelin (50 micrograms/kg) and riboxin (15 mg/kg) intramuscularly or nonachlazin (20 mg/kg) per os showed that blood fibrinolytic activity drops down. Concurrently the fibrinogen titer is increased. Prolonged intramuscular administration of complamin in a dose of 15 mg/kg activates fibrinolysis in rats and decreases fibrinogen concentration.