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. 1978;43(3-4):271-7.
doi: 10.1007/BF01246964.

Amphetamine and 2-phenylethylamine in post-mortem Parkinsonian brain after (-)deprenyl administration

G P Reynolds, P Riederer, M Sandler, K Jellinger, D Seemann

Amphetamine and 2-phenylethylamine in post-mortem Parkinsonian brain after (-)deprenyl administration

G P Reynolds et al. J Neural Transm. 1978.

Abstract

Deprenyl is an inhibitor of monoamine oxidase type B, the enzyme responsible for 2-phenylethylamine oxidation, and is used in conjunction with L-Dopa therapy in Parkinson's disease. Post-mortem studies in human brain tissue have shown that after (-)deprenyl administration to parkinsonian patients amphetamine is present in concentrations up to 56 ng/g. It also could be shown that phenylethylamine concentrations are substantially increased in such patients. Phenylethylamine and amphetamine have been investigated using a gas chromatographic technique.

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References

    1. Arzneimittelforschung. 1975 Apr;25(4):622-6 - PubMed
    1. J Neurochem. 1980 May;34(5):1123-5 - PubMed
    1. Lancet. 1977 Oct 15;2(8042):791-5 - PubMed
    1. Nature. 1977 Jan 6;265(5589):80-1 - PubMed
    1. J Pharmacol Exp Ther. 1973 Nov;187(2):365-71 - PubMed

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