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. 1980 Nov;361(11):1751-6.

[Mechanism of silybin action, III. Resorption of the flavonolignane derivative silybin into rat liver cells (author's transl)]

[Article in German]
J Sonnenbichler, J Mattersberger, G Hanser
  • PMID: 7450686

[Mechanism of silybin action, III. Resorption of the flavonolignane derivative silybin into rat liver cells (author's transl)]

[Article in German]
J Sonnenbichler et al. Hoppe Seylers Z Physiol Chem. 1980 Nov.

Abstract

After tritium labelling of silybin the time-dependent uptake of the flavonolignane derivative into rat liver was measured. Within the liver cells the distribution of silybin (and -metabolites) in cytosol, nuclear constituents and membrane material was determined and the accumulation of the flavonolignane derivative in cytosol and nuclear membranes confirmed by autoradiography. Within the nuclei a preferential binding on chromosomal proteins was found.

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