Interaction of phenylbutazone and tolbutamide in man
- PMID: 7450929
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Interaction of phenylbutazone and tolbutamide in man
Int J Clin Pharmacol Ther Toxicol.
1980 Sep.
Abstract
Phenylbutazone pretreatment increases tolbutamide half-life, whereas tolbutamide pretreatment decreases phenylbutazone half-life in man. Clinically, phenylbutazone may enhance the hypoglycemic action of tolbutamide, and tolbutamide may reduce the therapeutic effect of phenylbutazone.
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