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. 1980 Sep;18(9):378-80.

Interaction of phenylbutazone and tolbutamide in man

M Szita, B Gachályi, M Tornyossy, A Káldor
  • PMID: 7450929

Interaction of phenylbutazone and tolbutamide in man

M Szita et al. Int J Clin Pharmacol Ther Toxicol. 1980 Sep.

Abstract

Phenylbutazone pretreatment increases tolbutamide half-life, whereas tolbutamide pretreatment decreases phenylbutazone half-life in man. Clinically, phenylbutazone may enhance the hypoglycemic action of tolbutamide, and tolbutamide may reduce the therapeutic effect of phenylbutazone.

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