Influx of gamma-aminobutyric acid and alpha-aminoisobutyric acid into mouse cerebrum slices incubated in a pyruvate medium with or without added glucose or glucose analogues compared with influx from a glucose medium

Abstract

Concentrative influx of gamma-aminobutyric acid (GABA) and alpha-amino-isobutyric acid (AIB) into incubated mouse cerebrum slices is decreased when pyruvate is substituted for glucose. Influx of GABA from pyruvate medium is not increased by presence of glucose, 2-deoxy-D-glucose (2-DOG), or 3-O-methyl-D-glucose (3-O-MeG). Influx of AIB is restored to the rate from glucose medium if 2-DOG is present initially, but is not restored if 2-DOG is added with AIB. Influx is not restored if 3-O-MeG is present initially, but is restored if 3-O-MeG is added with AIB. Influx is restored if glucose is present initially or is added with AIB.