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. 1981 Feb 6;211(4482):584-6.
doi: 10.1126/science.7455696.

Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E

R E Gregg, L A Zech, E J Schaefer, H B Brewer Jr

Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E

R E Gregg et al. Science. .

Abstract

The apolipoprotein E isolated from plasma of individuals with type III hyperlipoproteinemia (HLP) shows an abnormal pattern when it is examined by isoelectric focusing. Compared to apolipoprotein E from normal subjects, apolipoprotein E isolated from subjects with type III HLP had a decreased fractional catabolic rate in vivo in both type III HLP patients and normal individuals. The delayed catabolism of apolipoprotein E in type III HLP patients may be responsible for the lipid and lipoprotein abnormalities characteristic of these patients.

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