Comparative Study
doi: 10.1016/s0140-6736(78)90002-8.
A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism
- PMID: 74565
- DOI: 10.1016/s0140-6736(78)90002-8
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Comparative Study
A role for purine metabolism in the immune response: Adenosine-deaminase activity and deoxyadenosine catabolism
Lancet.
.
Abstract
We have investigated a new hypothesis for the association between adenosine deaminase (A.D.A.) deficiency and immunodeficiency--namely, that deoxyadenosine rather than adenosine (an equally effective A.D.A. substrate) is toxic to proliferating cells of lymphoid origin. This possibility was explored in mitogen-stimulated lymphocytes cultured with a potent A.D.A. inhibitor, E.H.N.A. (erythro-9[2-hydroxy-3-nonyl] adenine) to simulate A.D.A. deficiency. In this in-vitro system deoxyadenosine was inhibitory at much lower and more physiological concentrations (1 mumol/1), compared with adenosine (100 mumol/1).
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