Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Nov;42(5):692-6.
doi: 10.1038/bjc.1980.303.

Survival of intestinal crypts after treatment by adriamycin alone or with radiation

J V Moore, D A Broadbent
Free PMC article

Survival of intestinal crypts after treatment by adriamycin alone or with radiation

J V Moore et al. Br J Cancer. 1980 Nov.
Free PMC article

Abstract

A survival curve has been established for jejunal crypts of BDF1 mice treated by single i.p. doses of the antibiotic agent adriamycin. The threshold dose and Do were twice that for marrow CFU-S of these mice. The overall extrapolation number of the crypt survival curve was very low (1.3 +/- 0.13) compared to the value for gamma radiation. This observation is discussed with respect to the interpretation of crypt survival curves. We were unable to demonstrate any enhancement by adriamycin (reduction in Dq) of the response of microcolony-forming cells to radiation given immediately before the drug.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Radiat Res. 1979 Oct;80(1):92-107 - PubMed
    1. Radiat Res. 1961 Feb;14:213-22 - PubMed
    1. Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1261-4 - PubMed
    1. Int J Radiat Oncol Biol Phys. 1979 Apr;5(4):501-6 - PubMed
    1. Radiat Res. 1976 Jul;67(1):162-7 - PubMed