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. 1978 Dec;5(12):4805-18.
doi: 10.1093/nar/5.12.4805.

An octamer of histones H3 and H4 forms a compact complex with DNA of nucleosome size

R H Simon, R D Camerini-Otero, G Felsenfeld
Free PMC article

An octamer of histones H3 and H4 forms a compact complex with DNA of nucleosome size

R H Simon et al. Nucleic Acids Res. 1978 Dec.
Free PMC article

Abstract

Equimolar mixtures of histones H3 and H4 have been reconstituted onto DNA of nucleosome core size. Two distinct complexes are formed in a relative abundance that depends on the starting ratio of H3 + H4 to DNA. One of these complexes contains two H3-H4 dimers for each DNA molecule, and has a sedimentation coefficient of 7.5S. The other complex contains an octamer consisting of four H3-H4 dimers, and has a sedimentation coefficient of 10.4S. On the basis of these measurements, we conclude that the octamer complex (but not the tetramer complex) is a fully folded, compact structure resembling the nucleosome.

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