Comparative Study
doi: 10.1016/s0140-6736(78)90611-6.
Antibiotic treatment of guinea-pigs infected with agent of Legionnaires' disease
- PMID: 74604
- DOI: 10.1016/s0140-6736(78)90611-6
Item in Clipboard
Comparative Study
Antibiotic treatment of guinea-pigs infected with agent of Legionnaires' disease
Lancet.
.
Abstract
Erythromycin and rifampicin (rifampin) were able to prevent death of guineapigs given intraperitoneal injections of the agent causing legionnaires' disease. Penicillin, chloramphenicol, tetracycline, and gentamicin showed no significant effect. On the basis of clinical experience and experimental observations, erythromycin is recommended for patients suspected to have legionnaires' disease. Combined therapy with erythromycin and rifampicin may be justified in patients with confirmed legionnaires' disease who are not responding to erythromycin alone or as part of a controlled antibiotic trial among suspected cases during an outbreak of legionnaires' disease.
Similar articles
-
Antimicrobial therapy of experimentally induced Legionnaires' disease in guinea pigs.Am Rev Respir Dis. 1984 Nov;130(5):849-56. doi: 10.1164/arrd.1984.130.5.849. Am Rev Respir Dis. 1984. PMID: 6333840
-
Comparison of the activity of three antibiotic regimens in severe Legionnaires' disease.J Antimicrob Chemother. 1990 Oct;26 Suppl B:129-39. doi: 10.1093/jac/26.suppl_b.129. J Antimicrob Chemother. 1990. PMID: 2258340
-
Antibiotic therapy of experimental airborne Legionnaires' disease.J Infect. 1983 Nov;7(3):210-7. doi: 10.1016/s0163-4453(83)97034-2. J Infect. 1983. PMID: 6663081
-
Antimicrobial chemotherapy for legionnaires' disease: a review.Clin Infect Dis. 1995 Dec;21 Suppl 3:S265-76. doi: 10.1093/clind/21.supplement_3.s265. Clin Infect Dis. 1995. PMID: 8749675 Review.
-
Legionnaires' disease. A review.Chest. 1984 Jan;85(1):114-20. doi: 10.1378/chest.85.1.114. Chest. 1984. PMID: 6360569 Review. No abstract available.
Cited by
-
Response of Legionella pneumophila to beta-lactam antibiotics.Antimicrob Agents Chemother. 1985 May;27(5):695-700. doi: 10.1128/AAC.27.5.695. Antimicrob Agents Chemother. 1985. PMID: 2409915 Free PMC article.
-
Legionellosis.Am J Pathol. 1981 Jun;103(3):429-65. Am J Pathol. 1981. PMID: 7015873 Free PMC article. Review. No abstract available.
-
Legionnaires' disease in a renal transplant recipient.Can Med Assoc J. 1979 Jun 23;120(12):1537-9. Can Med Assoc J. 1979. PMID: 378344 Free PMC article. No abstract available.
-
Antimicrobial therapy of experimental Legionella micdadei pneumonia in guinea pigs.Antimicrob Agents Chemother. 1985 Dec;28(6):730-4. doi: 10.1128/AAC.28.6.730. Antimicrob Agents Chemother. 1985. PMID: 3878688 Free PMC article.
-
Direct activation of human monocyte-derived macrophages by a bacterial glycoprotein extract inhibits the intracellular multiplication of virulent Legionella pneumophila serogroup 1.Infect Immun. 1987 Sep;55(9):2234-9. doi: 10.1128/iai.55.9.2234-2239.1987. Infect Immun. 1987. PMID: 3623700 Free PMC article.