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. 1980 Oct;5(10):1107-16.
doi: 10.1007/BF00966168.

Stability of the glutamate content of synaptosomes during their preparation

J W Geddes, J D Newstead, J D Wood

Stability of the glutamate content of synaptosomes during their preparation

J W Geddes et al. Neurochem Res. 1980 Oct.

Abstract

The glutamate content of synaptosomal-enriched fractions is stable during the preparation and isolation of the organelles provided that the temperature of the preparation is maintained at 0--2 degrees C and that inorganic ions are not added to the homogenizing and centrifugation media. Consequently, drug-induced in vivo changes in the glutamate content of nerve endings should be reflected by the corresponding changes in glutamate levels of synaptosomes prepared from the brain tissue.

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