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. 1978 Feb 4;1(8058):238-40.
doi: 10.1016/s0140-6736(78)90483-x.

Elevated beta-thromboglobulin levels and circulating platelet aggregates in diabetic microangiopathy

F E Preston, J D Ward, B H Marcola, N R Porter, W R Timperley, B C O'Malley

Elevated beta-thromboglobulin levels and circulating platelet aggregates in diabetic microangiopathy

F E Preston et al. Lancet. .

Abstract

beta-Thromboglobulin levels and platelet-aggregate ratios were determined in blood-samples from healthy control subjects and from diabetic patients with and without microangiopathic complications. Patients with diabetic microangiopathy had significantly elevated beta-thromboglobulin levels and also reversible platelet aggregates. In nine newly treated diabetics blood-glucose control was associated with a significant fall in plasma beta-thromboglobulin. Since beta-thromboglobulin is a platelet-specific protein the results indicate that diabetic microangiopathy is associated with evidence of platelet activation and that this may be influenced by the degree of biochemical control.

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