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. 1980 Mar;5(3-4):191-6.
doi: 10.1016/0378-4274(80)90058-2.

Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo

H Kieczka, H Kappus

Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo

H Kieczka et al. Toxicol Lett. 1980 Mar.

Abstract

Rat liver microsomes showed an atypical oxygen dependence of carbon tetrachloride (CCL4)-induced malondialdehyde formation with a maximum at ca. 7% O2 and a minimum at ca. 15% O2. Rats treated with CCl4 expired less ethane under high oxygen concentrations and more ethane under low oxygen concentrations. The initiation of CCl4-induced lipid peroxidation in the liver would appear to be influenced by the oxygen concentrations present in the hepatocytes.

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