Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980;71(2):359-61.
doi: 10.1111/j.1476-5381.1980.tb10947.x.

The interaction of trazodone with rat brain muscarinic cholinoceptors

D K Hyslop, D P Taylor

The interaction of trazodone with rat brain muscarinic cholinoceptors

D K Hyslop et al. Br J Pharmacol. 1980.

Abstract

The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate in vitro was used for comparing atropine-like effects. Trazodone was found to have essentially no activity at the muscarinic acetylcholine binding site in comparison to the tricyclic antidepressants.

PubMed Disclaimer

References

    1. Psychopharmacol Bull. 1976 Jan;12(1):40-1 - PubMed
    1. Clin Pharmacol Ther. 1976 Jun;19(6):795-801 - PubMed
    1. Arch Gen Psychiatry. 1977 Feb;34(2):236-9 - PubMed
    1. Mol Pharmacol. 1978 Sep;14(5):751-67 - PubMed
    1. Commun Psychopharmacol. 1979;3(2):81-7 - PubMed

LinkOut - more resources