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. 1995 Nov 4;346(8984):1198-9.
doi: 10.1016/s0140-6736(95)92901-0.

Detection of diverse HIV-1 genetic subtypes in the USA

S K Brodine  1 , J R Mascola, P J Weiss, S I Ito, K R Porter, A W Artenstein, F C Garland, F E McCutchan, D S Burke
Affiliations

Detection of diverse HIV-1 genetic subtypes in the USA

S K Brodine et al. Lancet. .

Abstract

Of the nine genetic subtypes of HIV-1 that exist world wide, subtype B predominates in North America and Europe. Thus, most knowledge about HIV-1 and most vaccine development efforts are based on subtype B viruses. We document here the detection of HIV-1 subtypes A, D, and E in five US servicemen who acquired these non-subtype-B infections during overseas deployments. The dispersal of diverse HIV-1 subtypes into regions of the world with previously restricted genetic diversity may have important implications for the epidemiology of the epidemic and for the design and implementation of vaccine trials.

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