[The rate of polyploid fertilization of ovocytes in in vitro fertilization in patients with an increased ovarian response]

Abstract

Polyploid fertilization is a common cause of human embryo's early loss in in vivo (1-2%) and in in vitro fertilization (3-5%) as well. Cause of increased rate of polypoid fertilization in in vitro fertilization is multifactorial. The aim of this paper was to establish if high ovarian response to exogenous hormone stimulation of ovaries can be one of the causes of increased incidence of polyploid fertilization. The research included 125 patients from whom 568 ovocytes were obtained by ultrasound aspiratory punction of ovarian follicles. The gathered results point to the fact that exogenous ovarian stimulation and the degree of ovarian response have a significant influence on increase of polyploid fertilization's rate. Thus, in the group of patients from whom 11 or more ovocytes were obtained, the rate of polyploid fertilization amounted to 11.3%, whereas it is statistically significantly higher (p < 0.01) in regard to those in whom less important difference in the rate of polyploid fertilization considering applied schemes of ovulation's stimulation (p > 0.1) was not established nor was it established considering the age of patients (p > 0.05). Despite the fact that the rate of polyploid fertilization in in vitro conditions is higher that in the natural conception, this method of treating marital infertility opens a unique possibility to identify all irregularities considering fertilization and prevent development of such embryos on time as it happens at the very beginning of the preimplantational stage of ovum's fertilization in laboratory conditions.