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. 1978 Dec;59(6):624-9.

Effect of antibody avidity on the induction of renal injury in anti-glomerular basement membrane nephritis

F Shimizu, H Mossmann, H Takamiya, A Vogt

Effect of antibody avidity on the induction of renal injury in anti-glomerular basement membrane nephritis

F Shimizu et al. Br J Exp Pathol. 1978 Dec.

Abstract

Antibodies to glomerular basement membrane (GBM) of the rat could be fractionated according to their avidity by elution from trypsin-digested GBM (bound to Sepharose) with increasing concentrations of KSCN. The percentage of kidney-fixing antibody in each fraction and the degree of proteinuria induced as determined 24 h after injection increased with the avidity of the antibody fraction when equal doses were administered.

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References

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