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. 1995 Jun 30;193(2):109-12.
doi: 10.1016/0304-3940(95)11679-q.

Amoeboid microglial response following X-ray-induced apoptosis in the neonatal rat brain

I Ferrer  1 , M Olivé, R Blanco, J Ballabriga, C Cinós, A M Planas
Affiliations

Amoeboid microglial response following X-ray-induced apoptosis in the neonatal rat brain

I Ferrer et al. Neurosci Lett. .

Abstract

The phagocytic response following X-ray-induced apoptosis in the neonatal rat brain was examined by immunohistochemistry with the antibodies OX-6 and OX-42 which recognize MHC class II antigens and the CR3 complement receptor, respectively. Few OX-6-immunoreactive cells were observed in control rats, and in rats irradiated at postnatal day 2 and examined during the first 2 postnatal weeks. However, a transient increase in the number of OX-42-immunoreactive amoeboid microglia, containing large numbers of apoptotic cells, occurred at 6, 24 and 48 h after irradiation when compared with age-matched controls. These results show that X-ray-induced apoptosis promotes a short-lasting phagocytic response.

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