Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Nov 7;92(23):10477-81.
doi: 10.1073/pnas.92.23.10477.

Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response

A C Zelhof  1 , T P Yao, R M Evans, M McKeown
Affiliations

Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response

A C Zelhof et al. Proc Natl Acad Sci U S A. .

Abstract

In a search for retinoid X receptor-like molecules in Drosophila, we have identified an additional member of the nuclear receptor superfamily, XR78E/F. In the DNA-binding domain, XR78E/F is closely related to the mammalian receptor TR2, as well as to the nuclear receptors Coup-TF and Seven-up. We demonstrate that XR78E/F binds as a homodimer to direct repeats of the sequence AGGTCA. In transient transfection assays, XR78E/F represses ecdysone signaling in a DNA-binding-dependent fashion. XR78E/F has its highest expression in third-instar larvae and prepupae. These experiments suggest that XR78E/F may play a regulatory role in the transcriptional cascade triggered by the hormone ecdysone in Drosophila.

PubMed Disclaimer

References

    1. Cold Spring Harb Symp Quant Biol. 1974;38:655-62 - PubMed
    1. Mol Endocrinol. 1994 Dec;8(12):1667-80 - PubMed
    1. Science. 1987 Jul 17;237(4812):268-75 - PubMed
    1. Biochem Biophys Res Commun. 1988 Sep 15;155(2):971-7 - PubMed
    1. Biochem Biophys Res Commun. 1989 Dec 15;165(2):735-41 - PubMed

Publication types

MeSH terms

Associated data