Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 1995 Nov 10;270(5238):985-8.
doi: 10.1126/science.270.5238.985.

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

P Waterhouse  1 , J M Penninger, E Timms, A Wakeham, A Shahinian, K P Lee, C B Thompson, H Griesser, T W Mak
Affiliations
Comment

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

P Waterhouse et al. Science. .

Abstract

The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell blasts with up-regulated activation markers. These blast cells also infiltrated liver, heart, lung, and pancreas tissue, and amounts of serum immunoglobulin were elevated. The mice invariably became moribund by 3 to 4 weeks of age. Although CTLA-4-deficient T cells proliferated spontaneously and strongly when stimulated through the T cell receptor, they were sensitive to cell death induced by cross-linking of the Fas receptor and by gamma irradiation. Thus, CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis.

PubMed Disclaimer

Comment on

  • The Yin and Yang of T cell costimulation.
    Allison JP, Krummel MF. Allison JP, et al. Science. 1995 Nov 10;270(5238):932-3. doi: 10.1126/science.270.5238.932. Science. 1995. PMID: 7481795 Review. No abstract available.

Publication types

MeSH terms