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. 1978 Dec;4(6):453-62.

Inhibition of GH1 rat pituitary tumor cell adenylyl cyclase activity by somatostatin

J J Heindel, E Williams, G A Robison, S J Strada
  • PMID: 748397

Inhibition of GH1 rat pituitary tumor cell adenylyl cyclase activity by somatostatin

J J Heindel et al. J Cyclic Nucleotide Res. 1978 Dec.

Abstract

Somatostatin inhibits basal and chlorpromazine stimulated adenylyl cyclase activity in homogenates of GH1 rat pituitary tumor cells. The Dtryp8-Dcys14 analogue is more potent than tyrosyl somatostatin as an inhibitor of both basal and chlorpromazine-stimulated adenylyl cyclase. Somatostatin had no effect on sodium fluoride or quanylyl-imidodiphosphate-stimulated cyclase in GH1 cell homogenates or on basal, epinephrine or prostaglandin E1 stimulated cyclase activity in sonicated BHK fibroblasts. These results indicate a specific effect of somatostatin to inhibit pituitary adenylyl cyclase activity.

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