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. 1978 Feb 24;199(4331):893-5.
doi: 10.1126/science.74852.

Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning

J J Boylan, J L Egle, P S Guzelian

Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning

J J Boylan et al. Science. .

Abstract

In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.

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