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. 1995 Aug;39(8):1896-8.
doi: 10.1128/AAC.39.8.1896.

Timing of penicillin treatment influences the course of Streptococcus pneumoniae-induced middle ear inflammation

K Sato  1 , M K Quartey, C L Liebeler, G S Giebink
Affiliations

Timing of penicillin treatment influences the course of Streptococcus pneumoniae-induced middle ear inflammation

K Sato et al. Antimicrob Agents Chemother. 1995 Aug.

Abstract

Penicillin treatment timing, using the chinchilla pneumococcal otitis media model, was investigated. Early treatment (when approximately 10(3) pneumococcal CFU/ml was present in middle ear fluid) significantly accelerated inflammatory-cell influx, whereas late treatment (with approximately 10(7) pneumococcal CFU/ml present in middle ear fluid) did not. Therefore, antiinflammatory interventions will be needed early in the course of inflammation.

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