Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995;287(6):553-7.
doi: 10.1007/BF00374075.

Histopathological and immunohistochemical changes in psoriatic skin during peptide T treatment

T Talme  1 , B L Rozell, K G Sundqvist, L Wetterberg, J A Marcusson
Affiliations

Histopathological and immunohistochemical changes in psoriatic skin during peptide T treatment

T Talme et al. Arch Dermatol Res. 1995.

Abstract

Ten patients with plaque-type psoriasis were treated with 2 mg peptide T i.v. for 28 days. Six patients responded with a substantial clinical improvement. Sequential biopsies from skin lesions were taken before, during and after treatment. The histological score (defining the activity of the psoriasis), the epidermal thickness and the number of infiltrating dermal lymphocytes were all reduced in the six patients who responded to the treatment. An increase in the number of CD1+ dendritic cells was detected immunohistochemically in the epidermis of the responders. The nonresponders did not display any pronounced changes.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Acta Derm Venereol. 1989;69(2):175-8 - PubMed
    1. Clin Exp Immunol. 1985 Sep;61(3):526-34 - PubMed
    1. Acta Derm Venereol Suppl (Stockh). 1989;146:117-21 - PubMed
    1. Br J Dermatol. 1991 Dec;125(6):548-56 - PubMed
    1. J Exp Med. 1986 Oct 1;164(4):1013-28 - PubMed

Publication types

LinkOut - more resources