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Case Reports
. 1995 Jun;53(2):312-7.
doi: 10.1590/s0004-282x1995000200025.

Familial glioblastoma

W O Arruda  1 , R S Clemente, R Ramina, A A Pedrozo, R F Pilotto, W Pinto Júnior, L F Bleggi-Torres
Affiliations
Case Reports

Familial glioblastoma

W O Arruda et al. Arq Neuropsiquiatr. 1995 Jun.

Abstract

The authors describe a family with three members affected by glioblastoma. The proband patient, a 7 year-old girl, developed a rare complication, a pulmonary metastasis. Chromosomal analysis of her peripheral blood lymphocytes showed a normal karyotype (46, XX), without structural abnormalities. Cytogenetic study of the tumor cells disclosed several abnormalities: 46, XX, 7q-/46, XX, -2, 4p-, 7p-, +15/46, XX. Some aspects about genetics of glial neoplasms are discussed.

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