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Comparative Study
. 1995 Nov 2;216(1):78-83.
doi: 10.1006/bbrc.1995.2594.

Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog

X Wu  1 , C E Robinson, H W Fong, J S Crabtree, B R Rodriguez, B A Roe, J M Gimble
Affiliations
Comparative Study

Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog

X Wu et al. Biochem Biophys Res Commun. .

Abstract

Multiple serine/threonine kinases were detected in a bone marrow stromal cell line. One of these, the murine activin receptor like kinase-1 (ALK-1) homolog was cloned and sequenced. The expressed recombinant protein (62 kDa) was consistent in size with that predicted by the cDNA (58.6 kDa). On Western blots, a goat polyclonal antibody detected the native ALK-1 protein in bone marrow stromal cells, lung, brain, kidney and spleen. Two protein species of 60 kDa and 72-76 kDa were detected. Glycosylation events or alternative splicing may account for the larger protein specie.

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