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. 1995 Nov;41(5):582-6.
doi: 10.1007/BF00175816.

Sense in antisense?

D R Forsdyke  1
Affiliations

Sense in antisense?

D R Forsdyke. J Mol Evol. 1995 Nov.

Abstract

A correspondence between open reading frames in sense and antisense strands is expected from the hypothesis that the prototypic triplet code was of general form RNY, where R is a purine base, N is any base, and Y is a pyrimidine. A deficit of stop codons in the antisense strand (and thus long open reading frames) is predicted for organisms with high G + C percentages; however, two bacteria (Azotobacter vinelandii, Rhodobacter capsulatum) have larger average antisense strand open reading frames than predicted from (G + C)%. The similar codon frequencies found in sense and antisense strands can be attributed to the wide distribution of inverted repeats (stem-loop potential) in natural DNA sequences.

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