doi: 10.1038/ng1295-402.
The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance
Affiliations
- PMID: 7493020
- DOI: 10.1038/ng1295-402
Item in Clipboard
The VITESSE algorithm for rapid exact multilocus linkage analysis via genotype set-recoding and fuzzy inheritance
Nat Genet.
1995 Dec.
Abstract
As genetic marker maps have improved, multipoint linkage analysis has become a crucial part of all disease mapping studies. Paradoxically, multipoint lod scores become increasingly difficult to compute, particularly as the numbers of markers, marker alleles and untyped people increase. We have solved this problem by using a novel set-recording scheme to recode each person's genotype and 'fuzzy inheritance' to infer transmission probabilities. Our approach is implemented in a memory-efficient computer program, VITESSE, for extremely rapid computation of exact multipoint likelihoods. VITESSE enables fast and precise multipoint mapping of disease loci with highly polymorphic markers.
Comment in
-
How do you compute a lod score?Nat Genet. 1995 Dec;11(4):354-5. doi: 10.1038/ng1295-354. Nat Genet. 1995. PMID: 7493007 No abstract available.
Similar articles
-
Rapid multipoint linkage analysis via inheritance vectors in the Elston-Stewart algorithm.Hum Hered. 2001;51(4):226-40. doi: 10.1159/000053346. Hum Hered. 2001. PMID: 11287744
-
The full EM algorithm for the MLEs of QTL effects and positions and their estimated variances in multiple-interval mapping.Biometrics. 2005 Jun;61(2):474-80. doi: 10.1111/j.1541-0420.2005.00327.x. Biometrics. 2005. PMID: 16011694
-
Multipoint linkage analysis via Metropolis jumping kernels.Biometrics. 1996 Dec;52(4):1417-27. Biometrics. 1996. PMID: 8962460
-
A multilocus extension of the affected-pedigree-member method of linkage analysis.Am J Hum Genet. 1992 Apr;50(4):859-68. Am J Hum Genet. 1992. PMID: 1550129 Free PMC article. Review.
-
A random walk method for computing genetic location scores.Am J Hum Genet. 1991 Dec;49(6):1320-34. Am J Hum Genet. 1991. PMID: 1746559 Free PMC article. Review.
Cited by
-
Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23.Am J Hum Genet. 2001 Mar;68(3):661-73. doi: 10.1086/318788. Am J Hum Genet. 2001. PMID: 11179014 Free PMC article.
-
Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer.J Med Genet. 2004 Jun;41(6):407-12. doi: 10.1136/jmg.2003.017350. J Med Genet. 2004. PMID: 15173224 Free PMC article.
-
Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.PLoS One. 2013 Aug 2;8(8):e71779. doi: 10.1371/journal.pone.0071779. Print 2013. PLoS One. 2013. PMID: 23936524 Free PMC article.
-
Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33.Am J Hum Genet. 1998 Oct;63(4):1086-94. doi: 10.1086/302053. Am J Hum Genet. 1998. PMID: 9758611 Free PMC article.
-
Linkage of familial Hibernian fever to chromosome 12p13.Am J Hum Genet. 1998 Jun;62(6):1446-51. doi: 10.1086/301886. Am J Hum Genet. 1998. PMID: 9585614 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
