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Comparative Study
. 1978 Jul-Aug:(4):466-70.

[Laboratory and clinical study of biological activity of poly G-poly C complex]

[Article in Russian]
O A Aksenov, S E Bresler, A I Zakabunin, E M Kogan, V K Raĭt
  • PMID: 749342
Comparative Study

[Laboratory and clinical study of biological activity of poly G-poly C complex]

[Article in Russian]
O A Aksenov et al. Vopr Virusol. 1978 Jul-Aug.

Abstract

Poly(G).poly(C) inoculated intravenously to mice in a dose of 100 microgram induced interferon in the blood in amounts comparable to those induced by poly(I).poly (C). In contrast to rapid accumulation (within 2 hours after induction) and rapid disappearance of interferon in response to poly(I).poly(C) inoculation, the interferon induced by poly(G).poly(C) reached the maximum titer by 6 hours and remained at a high level for 24 hours after inoculation. When given to human volunteers intranasally in a dose of 6 mg, the poly(G).poly(C) complex induced interferon in the blood serum in 70% of the subjects in a titer of 85 units/ml within 24 hours.

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