Thalasselis syndrome and genetic theories on keratoconus

Abstract

Background: Previous theories of the pathogenesis of keratoconus have only described partial aspects of the disease.

Methods: Studies are reviewed that have demonstrated a statistical and physiological relation between keratoconus, magnesium deficiency, type A behavior, and allergy, which constitute the Thalasselis Syndrome.

Results: The Thalasselis syndrome integrates old and new theories on keratoconus, mitral valve prolapse, and tetany/menopause. Keratoconus is also associated with genetic diseases like Down syndrome, Marfan syndrome, and other conditions related to collagen disturbance and biochemical abnormalities in protein synthesis.

Conclusions: This syndrome suggests that the genetic disturbance that causes these alterations could be influenced by metabolic factors in which magnesium deficiency could be involved.