Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Dec;25(6):549-64.
doi: 10.1007/BF01582024.

The phylogeny of tRNAs seems to confirm the predictions of the coevolution theory of the origin of the genetic code

M Di Giulio  1
Affiliations

The phylogeny of tRNAs seems to confirm the predictions of the coevolution theory of the origin of the genetic code

M Di Giulio. Orig Life Evol Biosph. 1995 Dec.

Abstract

An extensive analysis of the evolutionary relationships existing between transfer RNAs, performed using parsimony algorithms, is presented. After building up an estimate of the tRNA ancestral sequences, these sequences are then compared using certain methods. The results seem to suggest that the coevolution hypothesis (Wong, J.T., 1975, Proc. Natl. Acad. Sci. USA 72, 1909-1912) that sees the genetic code as a map of the biosynthetic relationships between amino acids is further supported by these results, as compared to the hypotheses that see the physicochemical properties of amino acids as the main adaptative theme that led to the structuring of the genetic code.

PubMed Disclaimer

References

    1. J Theor Biol. 1994 May 7;168(1):43-51 - PubMed
    1. Physiol Chem Phys Med NMR. 1989;21(3):237-42 - PubMed
    1. Nature. 1966 Apr 2;210(5031):25-8 - PubMed
    1. J Mol Evol. 1993 Dec;37(6):662-4 - PubMed
    1. Orig Life Evol Biosph. 1992;22(5):309-19 - PubMed