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. 1978;37(8):1305-9.

[Changes in the liver following a single administration of 11-H-eicosafluoroundecanoic acid in rats]

[Article in German]
P Schmidt, D Burck, A Bürger
  • PMID: 749467

[Changes in the liver following a single administration of 11-H-eicosafluoroundecanoic acid in rats]

[Article in German]
P Schmidt et al. Acta Biol Med Ger. 1978.

Abstract

A single oral administration of 27 mg 11-H-eicosafluorundecanoic acid/kg of body weight (according to 1/20 of the oral LD50; 0.049 mM) resulted in a long lasting hepatomegaly in male rats. This was accompanied by a decrease of the triglyceride and total lipid levels in blood serum, a temporary increase of the total lipids in the liver, and an increase of the hexobarbital sleeping time, the latter being normalized before the liver/body weight ratio reached the control level. The bromothalein elimination and the S-alanine amino transferase and S-alkaline phosphatase activities were not affected.

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