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Review
. 1995 Dec;62(6 Suppl):1347S-1356S.
doi: 10.1093/ajcn/62.6.1347S.

Determination of optimal vitamin C requirements in humans

Affiliations
Review

Determination of optimal vitamin C requirements in humans

M Levine et al. Am J Clin Nutr. 1995 Dec.

Abstract

Although the recommended dietary allowance provides an estimate for vitamin C ingestion in humans, optimal vitamin C requirements are unknown. We define optimal vitamin C requirements operationally based on the following: dose-function relations, availability in the food supply, steady state concentrations in plasma and tissues achieved at each dose of vitamin C, urinary excretion, bioavailability, toxicity, and epidemiologic observations. Optimal vitamin C requirements can be estimated when information is available for at least some of these criteria.

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