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Case Reports
. 1995 Sep;54(9):752-3.
doi: 10.1136/ard.54.9.752.

Increased serum IgE level and interleukin-4 release from cultured lymphocytes from a patient with adult onset Still's disease

K Yokoi  1 , E Hosoi, M Nakanishi, T Goto, S Saito
Affiliations
Case Reports

Increased serum IgE level and interleukin-4 release from cultured lymphocytes from a patient with adult onset Still's disease

K Yokoi et al. Ann Rheum Dis. 1995 Sep.

Abstract

Objective: To evaluate the relationship between high serum levels of IgE and the release of interleukin-4 (IL-4) from cultured lymphocytes of a patient with adult onset Still's disease.

Methods: IL-4 concentrations in plasma and culture from inactivated peripheral blood mononuclear cells were assessed by enzyme immunoassay during febrile episodes and remission.

Results: A high level of IL-4 was detected by enzyme immunoassay in the peripheral blood mononuclear cells cultured from the patient. These seemed to correspond with a febrile episode and a high serum IgE concentration.

Conclusion: Increased serum IgE concentrations during a febrile episode are rare in patients with adult onset Still's disease, but the relationship between the high levels of serum IgE and IL-4 in cultured lymphocytes may provide clues to pathogenesis of the condition.

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