Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1995 Aug;7(4):472-83.
doi: 10.1016/0955-0674(95)80003-4.

Aquaporin water channels: unanswered questions and unresolved controversies

P Agre  1 , D Brown, S Nielsen
Affiliations
Review

Aquaporin water channels: unanswered questions and unresolved controversies

P Agre et al. Curr Opin Cell Biol. 1995 Aug.

Abstract

The long-standing biophysical question of how water crosses plasma membranes has been answered by the recent discovery of the aquaporins. Identification of this large family of membrane water-transport proteins has generated new questions about the physiological functions, tissue distributions, and regulatory mechanisms of individual aquaporins. The fast pace of developments in this field has also resulted in major discrepancies in published reports which warrant resolution.

PubMed Disclaimer

Similar articles

  • Water channels.
    Harris HW Jr, Zeidel ML. Harris HW Jr, et al. Curr Opin Nephrol Hypertens. 1993 Sep;2(5):699-707. doi: 10.1097/00041552-199309000-00003. Curr Opin Nephrol Hypertens. 1993. PMID: 7522911 Review.
  • [Aquaporins: membrane protein water channels].
    Fernández-Llama P, Botey A. Fernández-Llama P, et al. Med Clin (Barc). 1996 May 4;106(17):656-8. Med Clin (Barc). 1996. PMID: 8691911 Spanish. No abstract available.
  • [Aggrephores and aquaporins].
    Verbavatz JM. Verbavatz JM. C R Seances Soc Biol Fil. 1995;189(2):191-7. C R Seances Soc Biol Fil. 1995. PMID: 8590218 Review. French.
  • The aquaporin water channels.
    Agre P. Agre P. Proc Am Thorac Soc. 2006;3(1):5-13. doi: 10.1513/pats.200510-109JH. Proc Am Thorac Soc. 2006. PMID: 16493146 Free PMC article. Review. No abstract available.
  • [Aquaporin water channels].
    Ishibashi K. Ishibashi K. Nihon Rinsho. 1996 Mar;54(3):685-91. Nihon Rinsho. 1996. PMID: 8904224 Review. Japanese.
See all similar articles

Cited by

See all "Cited by" articles

References

    1. Agre P, Preston GM, Smith BL, Jung JS, Raina S, Moon C, Guggino WB, Nielsen S. Aquaporin CHIP: the archetypal molecular water channel. Am J Physiol. 1993;34:F463–F476. - PubMed
    1. Knepper M. The aquaporin family of molecular water channels. Proc Natl Acad Sci USA. 1994;91:6255–6258. - PMC - PubMed
    1. Agre P, Sasaki S, Chrispeels MJ. Aquaporins: a family of water channel proteins [letter] Am J Physiol. 1993;34:F461. - PubMed
    1. Gorin MB, Yancey SB, Cline J, Revel JP, Horwitz J. The major intrinsic protein (MIP) of lens fiber membrane. Cell. 1984;39:49–59. - PubMed
    1. Maurel C, Reizer J, Schroeder JI, Chrispeels MJ. The vacuolar membrane protein γ-TIP creates water specific channels in Xenopus oocytes. EMBO J. 1993;12:2241–2247. - PMC - PubMed

Publication types

LinkOut - more resources