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. 1994 Jan;1(1):109-10.
doi: 10.1128/cdli.1.1.109-110.1994.

Transforming growth factor beta in Alzheimer's disease

C C Chao  1 , S Hu, W H Frey 2nd, T A Ala, W W Tourtellotte, P K Peterson
Affiliations

Transforming growth factor beta in Alzheimer's disease

C C Chao et al. Clin Diagn Lab Immunol. 1994 Jan.

Abstract

Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients < 6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.

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