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. 1995 Aug 25;282(1-3):R1-2.
doi: 10.1016/0014-2999(95)00447-s.

Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A

M D Aceto  1 , S M Scates, J A Lowe, B R Martin
Affiliations

Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A

M D Aceto et al. Eur J Pharmacol. .

Abstract

Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole carboxamide.HCl). This demonstration should provide a powerful stimulus for the systematic study of dependency on the psychoactive cannabinoids.

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