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. 1995 Sep 5;283(1-3):R1-3.
doi: 10.1016/0014-2999(95)00438-q.

First delineation of 5-HT1A receptors in human brain with PET and [11C]WAY-100635

V W Pike  1 , J A McCarron, A A Lammerstma, S P Hume, K Poole, P M Grasby, A Malizia, I A Cliffe, A Fletcher, C J Bench
Affiliations

First delineation of 5-HT1A receptors in human brain with PET and [11C]WAY-100635

V W Pike et al. Eur J Pharmacol. .

Abstract

The selective 5-HT1A receptor radioligand, [11C]WAY-100635 ([11C]N-2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2- pyridyl)cyclohexanecarboxamide), has been injected intravenously into healthy male volunteers and studied by PET (positron emission tomography). The results provide the first delineation of 5-HT1A receptors in living human brain and demonstrate the potential to use [11C]WAY-100635 for the study of central 5-HT1A receptors in patients with psychiatric and neurological disorders and for the investigation of the pharmacology of drugs acting on the central nervous system.

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